Prof. Eunjin Cho‘s research project aims to implement a nickel catalyst system that is not sensitive and reacts in mild conditions to use it then to synthesize various functional heteropolycycles.

Heterocycle is a vital component widely found in physiologically active substances and materials, and various heterocycle synthesis methods have been developed and used. Still, synthesizing multiple heterocycles with multiple substituents takes a lot of time and cost. Through this study, it is possible to construct a new library by synthesizing multi-heterocyclic compound derivatives with various substituents that could not be easily synthesized; developing a leading synthetic pathway will be a good guide for derivative synthesis and bioactivity testing in follow-up studies.

It is a unique project requiring continuous research in basic science to develop an inexpensive nickel catalyst system with low toxicity. The completed synthesis roadmap is expected to contribute to the development of related fields by enabling the exploration of structure-activity correlation in new drug development, biomedical science, and material research.