Asymmetric Alkene Functionalization Enabled by Electrochemical Generation of Chiral Environment via Non covalent Interactions
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Affiliation
POSTECH Department of Chemistry
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E-Mail
khw7373@postech.ac.kr
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Award-winning achievements
Professor Hyunwoo-Kim aims to induce asymmetric reactions in a specific chiral environment.
The goal is achieved by introducing electrochemical oxidation techniques into organic reactions, which selectively supply the reaction potential. An effective stereo-discriminative model is proposed by kinetically controlling the generation of charged reaction intermediates from alkenes and maximizing non-covalent interactions with chiral anion catalysts.
This research establishes a library of candidate chiral anions necessary for new asymmetric synthesis, and the constructed library broadly applies to asymmetric synthetic methodology
through non-covalent interactions. Moreover, the synthetic anions used in the study can serve
as the basis for exploring synthesis of various derivatives, given their thermal stability, electrolytic stability, and electrical conductivity.
Synthesizing strategy to induce asymmetric activation reactions in alkenes electrochemically, without catalysts, distinguishes this project as a unique venture from traditional organic synthesis methods. The research outcomes are anticipated to set a new paradigm in the related field. They are also expected to substantially impact securing foundational knowledge and original technologies for developing high-value-added pharmaceutical synthetic methods.