Universal Theory for Sequence-dependent Material Properties of Heteropolymers
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Affiliation
Pusan National University Department of Chemistry
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E-Mail
jmchoi@pusan.ac.kr
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Award-winning achievements
This project aims to overcome theoretical challenges by explaining the recently highlighted biomolecular condensation phenomena in heteropolymers. Combining analytical theory with simulation and machine learning, it will seek to maintain the explanatory power for individual systems while promoting a universally applicable theoretical understanding.
Particularly for biomolecular condensates, whose properties determine cellular functions, the project will focus on developing theoretical models to explain diffusion behavior and viscoelasticity. These models will then be applied to specific systems to verify their effectiveness. Based on the Stickers-and-Spacers(S&S) model, heteropolymer condensates will be analyzed as molecular networks, using network dynamics to understand their dynamic characteristics.
This research will play a crucial role in advancing fields such as life sciences, medicine, and materials science by providing an in-depth understanding of heteropolymer aggregation phenomena and presenting various potential applications.